inductively coupled plasma mass spectrometry
We use our ICP-MS primarily for elemental analysis and trace analysis. Trace analysis in chemistry involves detecting substances in very low concentrations or determining them quantitatively.
Semi-quantitative screen analyses are often carried out first to get an overview of the elements present (e.g. for subsequent risk analysis). If elements close to their limit values are present, a quantitative analysis can be used to determine the elements much more precisely. This is done by matrix adjustments of the calibration solutions and optimized measurement conditions.
| investigation method | inductively coupled plasma mass spectrometry |
| abbreviation | ICP-MS |
| Device type and equipment | Thermo Scientific iCAP Q |
| functional principle | The solubilized sample atoms are ionized. The deflection of the ions in an electric field is measured as a function of mass and charge. |
| Typical applications | Trace analysis, semi-quantitative measurement of approx. 60 elements per run as standard, quantitative measurement optimized for defined elements. |
| detection limit | typically 0.1 µg/l (element dependent) |
| Requirements for sample | approx. 1g solid sample for digestion approx. 10ml liquid sample |
| Accreditation / Certification | ISO17025, GMP |
Example applications for mass spectrometry
ICP-MS for pharmaceutical and chemical analysis
Mass spectrometry is used in the pharmaceutical and chemical industries primarily for trace analysis. It can be used as a quantitative measurement with up to 60 elements simultaneously or as a semi-quantitative measurement in the entire spectrum. It is therefore suitable for almost all types of impurities.
Find out more about our expertise in the field of CRO
ICP-MS for aluminum surfaces
Aluminum surfaces often require anodizing or coating systems. Both the bath analysis and the chemical composition of coating systems can be analyzed using mass spectrometry.
Find out more about our expertise in the field of aluminum surfaces.
ICP-MS for technical safety
In the field of technical safety, mass spectrometry is used, for example, to analyze the alloy composition of materials.
Find out more about our expertise in the field of technical safety.
Methods that might also interest you
An overview of further methods in the field of chemical analysis can be found in the “Chemistry Pharma” section.
These also include the following spectrometric methods:
