Chemical and Physical Analytics
with SAS and GMP for reliable analysis results
The analytical laboratories of Suisse Technology Partners Ltd. offer a comprehensive range of chemical and physical analytical services for various industrial sectors:
- Order analyses according to standards (EP, USP, DIN ISO, ASTM…)
- Order analyses according to customer methods and internally developed methods
- Analysis of cannabinoids and controlled substances
- Characterization of nanomaterials
- Release analytics
- Qualification of reference materials
The quality of the analysis results is regularly checked and confirmed by the Swiss Accreditation Service (SAS) according to ISO 17025 (test center number STS 0023).
Relevant areas are GMP certified. GMP certification is continuously monitored by Swissmedic, customer audits and internal audits.
Chromatography
Purity controls and assay determinations in the pharmaceutical industry, product controls in the chemical industry, pollutant analysis in the environmental sector - these are just a few examples of the many possible applications of chromatography.
Liquid and gas chromatographic analysis methods effectively separate mixtures of substances; various detection methods permit qualitative and quantitative statements or identify the individual substances of the samples to be analyzed.
Devices and methods
- HPLC - with DAD or RI
- UPLC
- UPLC-MS
- GPC - with Triple Detection
- GC-FID
- Headspace-GC
Inorganic Elemental Analysis
Whether metals, salts, liquids or organic samples, all types of substances and materials are examined for element contents or traces in inorganic elemental analysis using modern analytical instruments.
For example, the determination of heavy metals in pharmaceuticals, intermediates and raw materials according to ICH Q3D is an important field of application for elemental analysis. Semi-quantitative screening analyses from a combination of ICP-MS and ICP-OES often provide a valuable data basis for a subsequent risk analysis regarding heavy metal contents.
Experienced chemists search together with the customer for a meaningful and cost-optimized analysis method for his samples. Great attention is also paid to the correct digestion procedure (keyword: volatile elements).
ICP-MS - inductively coupled plasma - mass spectrometry
| method of examination | inductively coupled plasma - mass spectrometry |
| abbreviation | ICP-MS |
| device type and features | Thermo Scientific iCAP Q |
| operating principle | The dissolved atoms of the digested sample are ionized by an argon plasma. The ions are separated depending on their mass-to-charge ratio and measured in an electric field. |
| typical applications | Trace analysis, quantitative analysis of up to 60 elements simultaneously, semiquantitative screening analysis, Elemental Impurities in pharmaceutical samples. |
| limit of detection | typical 0.1 µg/l (element dependent) |
| sample requirements | approx. 1g solid sample for digestion approx. 10ml liquid sample |
| accreditation / certification | ISO17025, GMP |
ICP-AES - inductively coupled plasma - atomic emission spectroscopy
| method of examination | inductively coupled plasma - atomic emission spectroscopy |
| abbreviation | ICP-AES |
| device type and features | Variant Vista PRO Agilent 725 OES |
| operating principle | The dissolved sample is nebulized into an argon plasma and is excited to light emission. The element specific light emission is measured of up to 30 elements simultaneously. |
| typical applications | Analyis of elemental composition of metals, ceramics, organic pharmaceutical samples, water, solutions and eluates. |
| limit of detection | typically 50 µg/l (element dependent) |
| sample requirements | appr. 1g solid sample for digestion appr. 10ml liquid sample |
| accreditation / certification | ISO17025, GMP |
AAS - Flame atomic absorption spectroscopy
| method of examination | Flame Atomic Absorption Spectrometry |
| short character | AAS |
| device type and features | contrAA 300, Analytics Jena |
| functional principle | The dissolved sample is nebulized and atomized in a flame (e.g. acetylene). The element specific absorbtion is measured by just one light source for all elements (Xenon short-arc lamp). |
| typical applications | Determination of alkali and alkaline earth metals. Simultaneous, powerful background correction. Analysis often according to pharmacopeia. |
| limit of dection | typically 0.2 mg/l (element dependent) |
| sample requirements | approx. 10g solid sample for digestion approx. 100ml liquid sample |
| accreditation / certification | ISO17025, GMP |
SS - OES - spark source optical emission spectrometry
| method of examination | Spark source optical emission spectrometry |
| abbreviation | OES |
| device type and features | Spectro LAB S |
| functional principle | Generation of an arc load at the sample. The light emission is optically resolved and the intensity of light at element specific wavelength is measured. |
| typical applications | Chemical composition of aluminium alloys and ferrous materials. |
| limit of detection | typical: 1μg/g P and Pb: 5 μg/g Sb and Zn: 10 μg/g |
| sample requirements | metallic measuring surface: min. 18 x 18 mm surface must be flat thickness: min. 1 mm Al-foils partly analyzable |
| accreditation / certification | ISO17025 |
XRF - X-ray fluorescence spectrometry
| method of examination | X-Ray Fluorescence Spectrometry |
| abbreviation | XRF |
| device type and features | Bruker S2 PUMA |
| functional principle | The sample surface is activated by x-ray up to a depth of approx. 10μm. The element specific emitted x-ray (fluorescence) is used for the quantitative analysis. |
| typical applications | Determination of the elements with atomic number 11 (Na) up to 92 (U), semiquantitative screenig and analysis of metals, stones, ceramics, plastics. Layer thickness measurements are possible. |
| limit of detection | typically 100 µg/g (depending on element) |
| sample requirements | quantitative: 1g qualitative: 10mg solid or liquid ideal: powdered |
| accreditation / certification | ISO9001 |
C-/S- Analysator - Carbon / Sulfur Analyzer
| method of examination | Carbon/sulphur -analyzer |
| abbreviation | C-/S- Analyzer |
| device type and features | Leco CS 200 |
| functional principle | The sample is combusted in an oxygen flow. CO2 and SO2 is detected in the exhaust gas by an infrared measuring cell. |
| typical applications | Carbon determination in composite material. C and S determination in iron and ferrous alloys. |
| limit of detection | C : 0.002 % S : 0.01 % |
| sample requirements | 1g Solids (fine particles) Metals, organic materials |
| accreditation / certification | ISO9001 |
General Analytics
Suisse TP offers a wide range of general analytical methods for the qualitative and quantitative characterization of substance samples.
These can be water determination using Karl Fischer, determination of the particle size of nanomaterials with dynamic light scattering, spectrophotometry, titrations or classical wet chemical analysis methods.
Devices and methods
- Titration systems
- Particle size determination
- Karl Fischer Water determination
- UV/VIS photometer
- FT-IR
- Wet chemical methods
- Rheology
- Contact angle measurement
Polymer Analytics
Many products and intermediate products of the pharmaceutical and chemical industry are polymers. The possible applications of classical polymer analysis are correspondingly versatile.
Chromatographic methods are used as well as spectroscopic methods or thermal analysis methods. Great attention is paid to the different procedures for sample preparation (e.g. extraction, homogenization, etc.) before the actual analysis.
Devices and methods
- GPC with Triple Detection
- Spectroscopic analysis methods (FT-IR, RFA)
- Thermal analysis methods (DMA, TMA, DSC, TGA)
Physical Analytics
The identification of residues from reactors, the homogeneity of pressed pills or the layer thickness distribution of aluminum blisters; these are just a few of the questions that physical analysis deals with for the chemical and pharmaceutical industry.
Physical analytics uses destructive and non-destructive testing methods to investigate the composition, microstructure, surface properties and behavior of various materials from a wide variety of industries, such as the pharmaceutical packaging industry, medical technology, chemical plant engineering and many more.
Devices and methods
- Light microscopy, SEM (scanning electron microscopy), WYKO (white light interference microscopy)
- XRF (X-ray fluorescence spectrometer)
- XPS (X-ray photoelectron spectrometer)
- EDX (energy dispersive X-ray analysis)
- CT (Computer Tomography)
