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Pharma & Chemistry

Analytical Services

 

Chemical and Physical Analytics

with SAS and GMP for reliable analysis results

The analytical laboratories of Suisse Technology Partners Ltd. offer a comprehensive range of chemical and physical analytical services for various industrial sectors:

  • Order analyses according to standards (EP, USP, DIN ISO, ASTM…)
  • Order analyses according to customer methods and internally developed methods
  • Analysis of cannabinoids and controlled substances
  • Characterization of nanomaterials
  • Release analytics
  • Qualification of reference materials

 

The quality of the analysis results is regularly checked and confirmed by the Swiss Accreditation Service (SAS) according to ISO 17025 (test center number STS 0023).

Relevant areas are GMP certified. GMP certification is continuously monitored by Swissmedic, customer audits and internal audits.


Chromatography

 

Purity controls and assay determinations in the pharmaceutical industry, product controls in the chemical industry, pollutant analysis in the environmental sector - these are just a few examples of the many possible applications of chromatography.

Liquid and gas chromatographic analysis methods effectively separate mixtures of substances; various detection methods permit qualitative and quantitative statements or identify the individual substances of the samples to be analyzed.

Devices and methods

  • HPLC - with DAD or RI
  • UPLC
  • UPLC-MS
  • GPC - with Triple Detection
  • GC-FID
  • Headspace-GC

Inorganic Elemental Analysis

 

Whether metals, salts, liquids or organic samples, all types of substances and materials are examined for element contents or traces in inorganic elemental analysis using modern analytical instruments.

For example, the determination of heavy metals in pharmaceuticals, intermediates and raw materials according to ICH Q3D is an important field of application for elemental analysis. Semi-quantitative screening analyses from a combination of ICP-MS and ICP-OES often provide a valuable data basis for a subsequent risk analysis regarding heavy metal contents.

Experienced chemists search together with the customer for a meaningful and cost-optimized analysis method for his samples. Great attention is also paid to the correct digestion procedure (keyword: volatile elements).

ICP-MS - inductively coupled plasma - mass spectrometry

method of examination inductively coupled plasma - mass spectrometry
abbreviation ICP-MS
device type and features Thermo Scientific iCAP Q
operating principle The dissolved atoms of the digested sample are ionized by an argon plasma. The ions are separated depending on their mass-to-charge ratio and measured in an electric field.
typical applications Trace analysis, quantitative analysis of up to 60 elements simultaneously, semiquantitative screening analysis, Elemental Impurities in pharmaceutical samples.
limit of detection typical 0.1 µg/l (element dependent)
sample requirements approx. 1g solid sample for digestion
approx. 10ml liquid sample
accreditation / certification ISO17025, GMP

 

ICP-AES - inductively coupled plasma - atomic emission spectroscopy

method of examination inductively coupled plasma - atomic emission spectroscopy
abbreviation ICP-AES
device type and features Variant Vista PRO
Agilent 725 OES
operating principle The dissolved sample is nebulized into an argon plasma and is excited to light emission. The element specific light emission is measured of up to 30 elements simultaneously.
typical applications Analyis of elemental composition of metals, ceramics, organic pharmaceutical samples, water, solutions and eluates.
limit of detection typically 50 µg/l (element dependent)
sample requirements appr. 1g solid sample for digestion
appr. 10ml liquid sample
accreditation / certification ISO17025, GMP

 

AAS - Flame atomic absorption spectroscopy

method of examination Flame Atomic Absorption Spectrometry
short character AAS
device type and features contrAA 300, Analytics Jena
functional principle The dissolved sample is nebulized and atomized in a flame (e.g. acetylene). The element specific absorbtion is measured by just one light source for all elements (Xenon short-arc lamp).
typical applications Determination of alkali and alkaline earth metals. Simultaneous, powerful background correction. Analysis often according to pharmacopeia.
limit of dection typically 0.2 mg/l (element dependent)
sample requirements approx. 10g solid sample for digestion
approx. 100ml liquid sample
accreditation / certification ISO17025, GMP

 

SS - OES - spark source optical emission spectrometry

method of examination Spark source optical emission spectrometry
abbreviation OES
device type and features Spectro LAB S
functional principle Generation of an arc load at the sample. The light emission is optically resolved and the intensity of light at element specific wavelength is measured.
typical applications Chemical composition of aluminium alloys and ferrous materials.
limit of detection typical: 1μg/g
P and Pb: 5 μg/g
Sb and Zn: 10 μg/g
sample requirements metallic
measuring surface: min. 18 x 18 mm
surface must be flat
thickness: min. 1 mm
Al-foils partly analyzable
accreditation / certification ISO17025

 

XRF - X-ray fluorescence spectrometry

method of examination X-Ray Fluorescence Spectrometry
abbreviation XRF
device type and features Bruker S2 PUMA
functional principle The sample surface is activated by x-ray up to a depth of approx. 10μm. The element specific emitted x-ray (fluorescence) is used for the quantitative analysis.
typical applications Determination of the elements with atomic number 11 (Na) up to 92 (U), semiquantitative screenig and analysis of metals, stones, ceramics, plastics. Layer thickness measurements are possible.
limit of detection typically 100 µg/g (depending on element)
sample requirements quantitative: 1g
qualitative: 10mg
solid or liquid
ideal: powdered
accreditation / certification ISO9001

 

C-/S- Analysator - Carbon / Sulfur Analyzer

method of examination Carbon/sulphur  -analyzer
abbreviation C-/S- Analyzer
device type and features Leco CS 200
functional principle The sample is combusted in an oxygen flow. CO2 and SO2 is detected in the exhaust gas by an infrared measuring cell.
typical applications Carbon determination in composite material. C and S determination in iron and ferrous alloys.
limit of detection C : 0.002 %
S : 0.01 %
sample requirements 1g Solids (fine particles)
Metals, organic materials
accreditation / certification ISO9001

 

General Analytics

Suisse TP offers a wide range of general analytical methods for the qualitative and quantitative characterization of substance samples.

These can be water determination using Karl Fischer, determination of the particle size of nanomaterials with dynamic light scattering, spectrophotometry, titrations or classical wet chemical analysis methods.

Devices and methods

  • Titration systems
  • Particle size determination
  • Karl Fischer Water determination
  • UV/VIS photometer
  • FT-IR
  • Wet chemical methods
  • Rheology
  • Contact angle measurement

Polymere Analytics

Many products and intermediate products of the pharmaceutical and chemical industry are polymers. The possible applications of classical polymer analysis are correspondingly versatile.

Chromatographic methods are used as well as spectroscopic methods or thermal analysis methods. Great attention is paid to the different procedures for sample preparation (e.g. extraction, homogenization, etc.) before the actual analysis.

Devices and methods

  • GPC with Triple Detection
  • Spectroscopic analysis methods (FT-IR, RFA)
  • Thermal analysis methods (DMA, TMA, DSC, TGA)

Physical Analytics

The identification of residues from reactors, the homogeneity of pressed pills or the layer thickness distribution of aluminum blisters; these are just a few of the questions that physical analysis deals with for the chemical and pharmaceutical industry.

Physical analytics uses destructive and non-destructive testing methods to investigate the composition, microstructure, surface properties and behavior of various materials from a wide variety of industries, such as the pharmaceutical packaging industry, medical technology, chemical plant engineering and many more.

Devices and methods

  • Light microscopy, SEM (scanning electron microscopy), WYKO (white light interference microscopy)
  • XRF (X-ray fluorescence spectrometer)
  • XPS (X-ray photoelectron spectrometer)
  • EDX (energy dispersive X-ray analysis)
  • CT (Computer Tomography)

Contact for analytical services


Patrik Bachmann
analytics@suisse-tp.ch +41 52 551 1169